Floppy eyelid syndrome is commonly associated with which combination?

• A. Diabetes and hypertension
• B. Sleep apnea and diabetes
• C. Obesity and sleep apnea
• D. Obesity and conjunctivitis

Answer: (C)

Floppy eyelid syndrome is most strongly linked to obesity and obstructive sleep apnea. The eyelids become unusually lax and easily evert, a pattern seen more often in middle-aged, typically overweight individuals who also have sleep-disordered breathing. Chronic factors from obesity, along with repetitive nocturnal hypoxia and systemic changes seen in sleep apnea, contribute to connective tissue alterations that underlie the eyelid laxity. That combination—obesity with sleep apnea—best fits the typical patient and explains why this pairing is the classic association.

While diabetes and hypertension often accompany obesity, they are not the defining association for floppy eyelid syndrome, and conjunctivitis is not a characteristic linked feature.