Which is LEAST associated with a chalazion?

• A. Acne rosacea
• B. Preseptal cellulitis
• C. Seborrheic dermatitis
• D. Sebaceous gland carcinoma

Answer: (B)

Chalazion is a chronic granulomatous inflammation of a meibomian gland due to obstruction, leading to a sterile, lipogranulomatous reaction within the eyelid. It commonly occurs with conditions that disrupt the eyelid margin or oil glands, such as acne rosacea and seborrheic dermatitis, which promote meibomian gland dysfunction and blepharitis. Sebaceous gland carcinoma can also present in the same region and may mimic a chalazion, so it’s an important consideration in persistent or recurrent lesions.

Preseptal cellulitis, on the other hand, is an acute infection of the eyelid and periorbital tissues, not a result of meibomian gland blockage. Chalazion tends to be a non-tender, gradually enlarging, painless lump, whereas preseptal cellulitis presents with acute redness, warmth, swelling, and tenderness, often with systemic signs. Because chalazion is a sterile, chronic process of the meibomian glands, preseptal cellulitis is not typically associated with it.