Which of the following is NOT a potential etiology of neurotrophic keratopathy?

• A. Herpes zoster
• B. LASIK surgery
• C. Contact lens wear
• D. Angle recession glaucoma

Answer: (D)

Neurotrophic keratopathy happens when corneal innervation or trophic signaling is disrupted, so the surface can’t heal properly. Infections that involve the trigeminal nerve, like herpes zoster ophthalmicus, damage corneal nerves, reducing sensation and healing. Procedures that cut corneal nerves, such as LASIK, lower corneal sensitivity and can lead to persistent epithelial defects. Long-term contact lens wear can contribute by causing chronic hypoxia and irritation that impairs epithelial maintenance. Angle recession glaucoma, while related to trauma and elevated intraocular pressure, does not typically injure the corneal nerves, so it is not a usual cause of neurotrophic keratopathy.